Advanced Bone Support

Thorne Advanced Bone Support is a comprehensive supplement formulated to support bone density through aging. It combines dicalcium malate, dimagnesium malate, vitamin D3, boron, and active B vitamins—each chosen for bioavailability and their complementary roles in maintaining a healthy bone matrix.

Although everyone loses bone density as they age, certain groups are particularly at risk. As many as half of all women in the United States older than 65 should be concerned about maintaining good bone health. Thorne's Advanced Bone Support is a comprehensive bone support supplement.* It contains dicalcium malate and dimagnesium malate (two calcium or magnesium molecules each bound to one molecule of malic acid) for enhanced absorption and greater concentration of these important minerals.*

Adequate magnesium intake promotes bone density by optimizing the secretion of parathyroid hormone and facilitating active calcium transport to the bones.* Advanced Bone Support provides vitamin D3, which facilitates the absorption of calcium; boron, which assists the body's metabolism of vitamin D and estrogen; and B vitamins for healthy methylation, which mediates homocysteine levels, a known risk factor of low bone density.*

Research indicates that an elevated homocysteine level in the blood can interfere with the integrity of the bone matrix. Therefore, Advanced Bone Support contains methylcobalamin (an active form of vitamin B12), L-5-methyltetrahydrofolate (the active form of folic acid), and pyridoxal 5'-phosphate (the active form of vitamin B6) for their function in helping to maintain already normal homocysteine levels.* To provide a bone health formula that can be used by individuals taking a blood-thinning medication, Advanced Bone Support does not contain vitamin K.

As women age, they experience an overall increase in bone loss compared to bone formation, so a woman's concern about maintaining good bone health should begin well before menopause. Because some bone loss during menopause is inevitable, more bone a woman has "banked" earlier in life, the greater her peak bone mass as she begins to age. Hence, menopausal bone loss will have less of an adverse impact. Even women in the 18-35 year-old age group should make an effort to achieve good bone health, because physical inactivity, low body weight, eating disorders, and poor nutrition during these ages can have adverse impacts on bone health later in life.

Groups at particular risk for bone loss in addition to women include smokers, those with a sedentary lifestyle, individuals who consume excessive sugar, alcohol, or caffeine, small-boned individuals, Caucasians, Asians, and patients on steroid or anticonvulsant therapies for prolonged periods of time.

Suggested Use:

Take 2 capsules two times daily or as recommended by your health-care practitioner.

Warnings:

ALLERGY WARNING

This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PREGNANCY

If pregnant, consult your health-care practitioner before using this product.

INTERACTIONS

5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

Who Thorne Advanced Bone Support Is Designed For

• Women over 65 concerned about bone density: Addresses a population at elevated risk by supplying calcium and magnesium in malate-bound forms shown to support enhanced mineral absorption.
• Those seeking optimized vitamin D and calcium synergy: Vitamin D3 is included to facilitate calcium absorption, while boron supports the body's metabolism of vitamin D and estrogen.
• Anyone managing homocysteine levels through diet: Active B vitamins—methylcobalamin and L-5-methyltetrahydrofolate—support healthy methylation, which is associated with maintaining homocysteine levels already within a normal range.
• Adults building a long-term bone-health routine: A multi-nutrient formula that pairs well with weight-bearing activity and a mineral-rich diet as part of a proactive wellness approach.

Frequently Asked Questions

What makes the calcium and magnesium in Thorne Advanced Bone Support different from standard forms?

Thorne uses dicalcium malate and dimagnesium malate, which bind calcium or magnesium molecules to malic acid for enhanced absorption and greater mineral concentration compared to many conventional forms.

Why does Thorne Advanced Bone Support include B vitamins alongside calcium and vitamin D3?

The active B vitamins—methylcobalamin and L-5-methyltetrahydrofolate—support healthy methylation, which helps mediate homocysteine levels, a factor associated with bone matrix integrity.

Is Thorne Advanced Bone Support appropriate for men as well as women?

While the formula specifically notes that women over 65 are among those most at risk for bone density concerns, the comprehensive nutrient profile supports bone health across adults as part of a broader wellness routine.