B-Complex #12

Thorne B-Complex #12 provides a complete B vitamin complex in bioactive forms, including methylcobalamin (B12) and 5-MTHF folate — the active forms the body can use directly, without conversion — making it a practical choice for daily B vitamin support across a range of lifestyles and needs.

B-Complex #12 offers a complete vitamin B complex, with added vitamin B-12 and folate. Supplementing with the active forms of the B vitamins is extremely important to everyone, especially individuals who might not be able to convert non-active B vitamins to their active forms in the liver because of compromised liver function, poorly functioning enzymes, digestive disorders, or increasing age.* Vitamin B12 and folate are necessary for normal red blood cell formation, tissue and cellular repair, normal methylation and homocysteine metabolism, and DNA synthesis.* Thorne's B-Complex #12 supplies the active form of vitamin B12 – methylcobalamin – as well as the active form of folate – 5-MTHF. The other bioactive forms of the B vitamins in each capsule ensures you will get the most bioavailable vitamin B complex available.* B-Complex #12 is not derived from yeast.

Most of the B vitamins, with the exception of vitamin B12, are not stored in the body; consequently, they must be acquired daily from the diet in order to maintain optimal health.*

Vitamin B12 deficiency can be manifest with varying degrees of mental changes, such as confusion and irritability.* Certain prescription medications (for seizures, diabetes, arthritis, and cancer) can cause a deficiency of these important vitamins. The incidence of vitamin B12 and/or folate deficiency is high among the elderly. Pregnant women require an increased amount of folate for proper fetal development.* A woman who has a folate deficiency prior to pregnancy can expect that deficiency to be intensified during pregnancy.

B Complex #12 includes eight water-soluble B vitamins: thiamin (vitamin B1); riboflavin/riboflavin 5'-phosphate (vitamin B2); niacinamide (vitamin B3); pantothenic acid (vitamin B5); pyridoxine/pyridoxal 5'-phosphate (vitamin B6); methylcobalamin (vitamin B12); 5-MTHF (folate); and biotin; plus choline. Although each B vitamin is chemically distinct, they often work synergistically in various biochemical functions throughout the body – from cellular energy production, to healthy red blood cell formation, to healthy neurological function.*

A nutritional supplement that contains these active cofactors has enhanced bioavailability, ensuring the body gets the nutrients it needs.*

Suggested Use:

Take 1 capsule one to three times daily or as recommended by your health-care practitioner.

Warnings:

ALLERGY WARNING

This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PREGNANCY

If pregnant, consult your health-care practitioner before using this product.

INTERACTIONS

5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

When B-Complex #12 Fits Your Routine

• Daily B vitamin replenishment: Most B vitamins are not stored in the body and need to be consistently replenished through diet or supplementation, making a daily B-complex a straightforward addition to a wellness routine.
• Active-form preference: Those who specifically seek methylcobalamin and 5-MTHF — the bioactive forms of B12 and folate — rather than non-active precursors that require liver conversion will find both supplied here.
• Yeast-free formulation: Individuals who prefer to avoid yeast-derived B vitamins can use this formula, as B-Complex #12 is not derived from yeast.
• Broad population suitability: Thorne formulated this complex with bioavailability in mind, making it relevant for adults across varying ages and digestive considerations who want a well-absorbed B vitamin supplement.

Frequently Asked Questions

What makes Thorne B-Complex #12 different from a standard B-complex supplement?

B-Complex #12 supplies B vitamins in their bioactive forms — including methylcobalamin for B12 and 5-MTHF for folate — which the body can use directly without requiring conversion in the liver. It also contains additional B12 beyond a typical B-complex ratio.

Is Thorne B-Complex #12 suitable for people with yeast sensitivities?

Yes. Thorne B-Complex #12 is not derived from yeast, which distinguishes it from many conventional B vitamin supplements.

How often should B-Complex #12 be taken?

Because most B vitamins are not stored in the body and need to be obtained regularly, a daily routine is generally recommended — consult your healthcare provider for guidance specific to your needs.