5-MTHF 1 mg - 90 servings

$34.00

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Why We Chose This

# Why We Chose This If you're committed to optimizing your health, methylation—the biochemical process that supports everything from energy production to cognitive function—deserves your attention, and many active people have genetic variations that compromise this cycle. This bioavailable form of folate delivers the nutritional support your body needs to maintain heart health, mental clarity, and efficient fat metabolism so you can perform and recover at your best.

Thorne 5-MTHF 1 mg supplies active, methylated folate — the form the body can readily use — to support a healthy methylation cycle. Formulated for those with an MTHFR gene variation, it is designed to promote cardiovascular, brain, and bone health as part of a consistent daily wellness routine.

Folate is a key component in the body’s methylation cycle, a series of biochemical reactions that play a beneficial role in multiple body systems. Heart and brain health, cellular energy production, fat metabolism, liver detoxification, and bone health all rely on a healthy methylation cycle.

Approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally. For these individuals, methylated vitamins, like Thorne’s 5-MTHF, provide essential nutritional support.*

Benefits of Thorne 5-MTHF

Nutritional support for individuals who have an MTHFR gene mutation*
Supports production of key neurotransmitters – serotonin, melatonin, dopamine, and epinephrine – natural brain chemicals that play an important role in regulating brain function and mood*
Promotes cardiovascular, brain, and bone health by maintaining a healthy methylation cycle and a normal homocysteine level*
Supports healthy fetal brain and spinal cord development*
Promotes blood and nerve cell health*

Features of Thorne 5-MTHF

Suitable for individuals who have an MTHFR gene mutation*
Active, methylated folate (5-MTHF) means your body gets the highest benefit with the least additional work
1 mg 5-MTHF is recommended for support of fetal development during pregnancy*
Easy-to-take, small capsules

Tested for quality you can trust

This product has been third-party tested and certified to verify what's in the package matches what's on the label and to confirm it contains no unsafe levels of contaminants, such as heavy metals, pesticides, and microorganisms.

Suggested Use:

Take 1 capsule one to three times daily or as recommended by your health-care practitioner.

Warnings:

ALLERGY WARNING

This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PREGNANCY

If pregnant, consult your health-care practitioner before using this product.

INTERACTIONS

5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

Who 5-MTHF 1 mg Is Designed For

MTHFR gene variation: Provides methylated folate in its active form, supporting those whose bodies have difficulty converting standard folic acid through the methylation cycle.
Cardiovascular and brain health support: Helps maintain a healthy methylation cycle, which plays a role in supporting normal homocysteine levels and overall heart and brain function.
Mood and neurotransmitter support: A healthy methylation cycle is linked to the production of key brain chemicals, making this a thoughtful addition to a mood-conscious daily routine.
Prenatal and cellular health: Supports healthy fetal brain and spinal cord development, as well as blood and nerve cell health, for those planning or navigating pregnancy.

Frequently Asked Questions

What makes Thorne 5-MTHF different from regular folic acid?

Thorne 5-MTHF delivers folate in its active, methylated form, which the body can use directly without conversion. This is particularly relevant for individuals with an MTHFR gene variation, which can impair the body's ability to process standard folic acid.

Is Thorne 5-MTHF appropriate if I have an MTHFR gene mutation?

Thorne 5-MTHF is specifically formulated with methylated folate to support individuals who have an MTHFR gene variation. Consulting a healthcare provider is recommended before adding any supplement to your routine.