Grape Seed Extract

Thorne Grape Seed Extract provides oligomeric proanthocyanidins (OPCs) via the clinically studied Leucoselect Phytosome® complex, supporting the body's antioxidant defenses, vascular integrity, and connective tissue resilience as part of a consistent wellness routine.

The primary constituents of Thorne's grape seed extract are oligomeric proanthocyanidins (OPCs). OPCs have strong free-radical scavenging (antioxidant) ability, resulting in inhibition of oxidative damage and protection of blood vessels and other tissues.* OPCs have been shown to protect vascular endothelial cells from oxidative damage and appear to strengthen the resistance of cell membranes to injury and impairment.* OPCs also can bind copper and iron, thereby reducing their oxidative effects.* Grape Seed Extract contains Leucoselect Phytosome®, which have demonstrated in studies to reduce the oxidation of LDL-cholesterol in heavy smokers, and decrease oxidative stress in diabetics and in healthy individuals after a fatty meal.*

Evidence suggests OPCs enhance the cross-linkage of collagen in skin and other connective tissues.* OPCs have also been shown to decrease capillary permeability, which can be manifest as decreased bruising.* For example, clinical studies demonstrate reduced swelling and improved resolution of sports injuries in athletes who were given OPCs prior to a sporting event.*

A clinical study of 10 healthy volunteers analyzing the effect of OPC supplementation on biomarkers of oxidative stress found significantly increased levels of the antioxidant alpha-tocopherol in red blood cell membranes.*

In a randomized human trial, young healthy volunteers received 300 mg of Leucoselect phytosome daily or a placebo. Antioxidant activity was measured at multiple time-points during days one and five. Within 30 minutes after administration on day one, the antioxidant activity measured by "total radical-trapping antioxidant parameter" (TRAP) was significantly elevated compared to placebo.*

Suggested Use:

Take 1 capsule two to three times daily or as recommended by your health-care practitioner.

Warnings:

ALLERGY WARNING

This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

Grape Seed Extract contains grape seed phytosome - a plant extract complexed with phospholipids, which are derived from soy. Phospholipids contain no soy protein. There are no other soy-based ingredients in Grape Seed Extract.

PREGNANCY

If pregnant, consult your health-care practitioner before using this product.

INTERACTIONS

There are no known adverse interactions or contraindications at publication date.

How Thorne Grape Seed Extract Fits Your Wellness Routine

• Antioxidant support: OPCs are recognized for their free-radical scavenging properties, helping protect cells and tissues from oxidative damage.
• Vascular and capillary health: Clinical research on OPCs suggests support for healthy capillary permeability and vascular endothelial cell protection.
• Connective tissue and skin: Evidence points to OPCs' role in supporting collagen cross-linkage in skin and other connective tissues, making this a thoughtful addition to a recovery-focused routine.
• Active lifestyle support: Clinical studies have explored OPC supplementation in athletes, with findings related to swelling and recovery following sports activity.

Frequently Asked Questions

What makes Thorne Grape Seed Extract different from standard grape seed supplements?

Thorne's formula features Leucoselect Phytosome®, a patented OPC complex studied for its bioavailability and antioxidant activity in multiple clinical settings. Thorne is known for rigorous quality standards across its supplement line.

Who is Thorne Grape Seed Extract best suited for?

It is designed for adults seeking daily antioxidant support and those interested in maintaining vascular health and connective tissue integrity as part of a broader wellness routine. As with any supplement, consult a healthcare provider before starting.

What are OPCs and why do they matter in a grape seed extract supplement?

Oligomeric proanthocyanidins (OPCs) are the primary active constituents in grape seed extract, valued for their strong antioxidant capacity and ability to bind metals that contribute to oxidative stress. They are the compounds most studied for vascular and tissue-protective benefits.